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Observe Carefully (one)pentobarbital will lessen the extent or influence of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to a lessen in fentanyl plasma concentrations, lack of efficacy or, potentially, enhancement of the w